| Date | Location | Result | |
| Nov 13, 2021 | Hays, Kan. | Pittsburg State 34, Fort Hays St. 24 | Box score |
| Nov 06, 2021 | Pittsburg, Kan. | Washburn 28, Pittsburg State 26 | Box score |
| Oct 30, 2021 | Pittsburg, Kan. | Pittsburg State 26, Central Okla. 20 | Box score |
| Oct 23, 2021 | St. Joseph, Mo. | Pittsburg State 34, Missouri Western 14 | Box score |
| Oct 16, 2021 | Pittsburg, Kan. | Pittsburg State 59, Lincoln (Mo.) 7 | Box score |
| Oct 09, 2021 | Maryville, Mo. | Northwest Mo. St. 20, Pittsburg State 19 | Box score |
| Oct 02, 2021 | Joplin, Mo. | Pittsburg State 20, Mo. Southern St. 16 | Box score |
| Sep 25, 2021 | Pittsburg, Kan. | Pittsburg State 30, Emporia St. 28 | Box score |
| Sep 18, 2021 | Tahlequah, Okla. | Pittsburg State 48, Northeastern St. 13 | Box score |
| Sep 11, 2021 | Pittsburg, Kan. | Neb.-Kearney 28, Pittsburg State 17 | Box score |
| Sep 02, 2021 | Warrensburg, Mo. | Pittsburg State 35, Central Mo. 16 | Box score |